By age 13, Henrie got his first big break, landing a regular role as Petey Pitt on the Fox sitcom The Pitts. Henrie next landed a leading role in the Hallmark movie, Monster Makers, with Linda Blair and George Kennedy, and was asked to come back for another Hallmark movie, to play a role in Dead Hollywood Moms Society.
Due to his involvement with Disney Channel, Henrie competed in the 2008 Disney Channel Games. He was team captain of the Green Team, also known as the Cyclones. He has a role in the Disney Channel Original Movie Dadnapped. Before his role on Wizards of Waverly Place, he had a recurring role on That's So Raven as Cory's friend Larry. Henrie also has a recurring role on How I Met Your Mother, and made a guest appearance as himself in 2 episodes of Jonas L.A.. According to Reuters, Henrie was officially named the Grand Marshal for the 2009 Toyota Pro/Celebrity Race.
At the age of 18, Henrie got the role of Justin Russo in the Disney Channel Original Series, Wizards of Waverly Place. The show premiered on October 12, 2007. He was in the movie Wizards of Waverly Place: The Movie with the cast of the series. Henrie played as Justin Russo through the whole series. About a year after the finale a film, The Wizards Return: Alex vs. Alex premiered on March 15, 2013 without Henrie, but his character was mentioned.
Henrie is currently filming a movie Little Boy and plays the role of London Busbee. He is also part of the cast of Grown Ups 2 opposite Taylor Lautner and Adam Sandler.
Henrie signed a four album and two ep contract with Hollywood Records. His debut single Goodbye released on March 6, 2013. His second single released on June 2, 2013. His album is called "Beach Boys" which releases on July 19, 2013.
Henrie is credited with writing the special, Meet The Werewolves, on his show Wizards of Waverly Place.
Henrie has also directed a short film titled "Boo!". David will be directing his first movie called Turbo.
Henrie was born in Mission Viejo, California, the son of Linda (née Finocchiaro), a talent manager, and James Wilson Henrie, a producer formerly in real estate. He is the brother of actor Lorenzo Henrie. His maternal grandparents were Italian. His paternal grandfather was French-Canadian and his paternal grandmother was of English ancestry. Henrie was raised as a Roman Catholic, and, in a video chat, stated that he is "a Christian and always will be." He grew up in Phoenix, Arizona, and is an avid hockey fan.